The big benefit of being laid off and looking for a job is that you have all the time in the world to interview, you don't have to be secretive about the fact that you're looking, and you have a built in explanation for why you're looking that nobody will think twice about.
If you cast a wide net, you'll probably get a fair bit of interest. The one piece of advice I'd give around interviewing is to try to schedule some of your first interviews with companies that you're not necessarily that interested in to help you warm up, since you're going to be rusty. Don't try to go through the full interview cycle with those companies before interviewing with ones you have a lot of interest in (that may leave you in a position where a company you're not that interested in makes a good offer before you have a chance to interview with the ones you really want), but rather try to do the each round of interviews at a couple of less-interesting places a few days before you do the same round at your target places.