I decided not to use a framework. I spent about a month going over the "TodoMVC.com" demos with the intent to choose one but after a few weeks of pondering which one I concluded I didn't want to invest in any of them.

jQuery and Mustache.js do a lot and are easy to use. CouchDB and PouchDB are too and that gave me user authentication, a powerful server side DB, and offline-first/local-first features.

I've never regretted those decisions but I had no investment in SQL DBs. Over the years since I've seen other's who've did struggle with CouchDB and I get that. I came from using CGI.pm's "Save" and "Get" functions and CouchDB/PouchDB.js are similar in how you use them, but way better.