Full disclosure I haven't used Luxon nearly as much as I've used DayJS, but I would say IMO DayJS is way simpler and more intuitive, this is a very small thing but for example, why would they format Months, by "L" instead of by "M"?

The other reason I like DayJS over Luxon is the sheer number of plugins you can pull in to do various things. Like for example I was building an application where I had to build a weekly calendar form for a timesheet, the requirement was weeks start on Saturday and end of Friday.

In DayJS I was able to do this pretty easily by doing: dayjs().startOf('week').subtract(1, 'day') to get the start and then took the result and did res.add(6, 'days') to get the end. I'm not sure if Luxon has this type of functionality.

Lastly I like the plugin architecture rather than giving you everything up front. By default DayJS does not include any of those cool transformations like I talked about above, you have to pull them in as plugins from DayJS, this results in a bit more setup but smaller bundle sizes at the end of the day.