Adults or Children?
My friends were all "gifted kids" who hung out in the same social circle, and did lots (and lots) of drugs (acid, DMT, mushrooms, coke, weed) from age 15-18.
In all cases it was great until one time it was suddenly NOT great. Yes, I actually witnessed at least 3 "meltdowns" where someone started acting really, really scary-strange, "We should call his mom!" strange.
All of them have negative feelings towards drugs as adults. There was no internet then to look up correct dosage, "safe" usage. No reviewed darknet dealers selling "real stuff" vs. random shit you'd buy from a stranger at Lollapalooza. I don't know what to say, but it's true, I saw people get messed up (long-term) from hallucinogens and swear them off forever.