This is some absolutely wrong dosage, please don't ever take actual 400ug doses unless you really know what you're doing. Most tabs sold as 200ug are in the 30-80ug range, so people tend to severely overestimate the dosage.
I absolutely agree that non-experienced users should start off with low doses, no more than 100μg. I am very experienced with psychedelics and knew what I was getting into when I took higher amounts. My point was simply that low doses may not result in "life changing experiences", for some to experience that (such as myself) higher doses may be required.
Didn't the scientist discoving it take a "small" amount which is like 10x that much? I always find that story funny for some reason. In this day no scientist is just like "let me try a few mgs of this thing I created" lol