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Comment by sallystarace | Hacker News Reader

Dextromethorphan tolerance builds so rapidly. I have found the withdrawal to be hell after taking it legitimately for a cold longer than I realized. I have tried SSRIs and found that they also have a synergetic effect with Bupropion (good medicine). SSRIs also make me drowsy, but at least they can be sustainably taken daily for months.

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I had good luck with a prescribed combo of modafinil + buproprion. No drowsiness, much higher motivation.

Does that lower the seizure threshold at all? (I've had docs get on my case about bupropion + mild other medication that can in theory impact the seizure threshold) But I'd be interested - potentially - in trying this combo as things are pretty cobwebby in the brain department lately.

Modafinil alone didn’t have that effect?

It helped, but the combo beat both depression and lack of motivation much more effectively.

Sounds like me, except Vyvanse instead of Modafinol. Bupropion was the magic key. I thought my Vyvanse just wasn't working anymore.

Turns out I was just super depressed. Since switching meds I've lost a lot of weight because I don't have food cravings as much.

The way I think of it... Vyvanse keeps me focused when I get to work, but without Bupropion just getting out bed sometimes seems daunting. One gets me to start my day, the other keeps me focused when I do.

What dosage of modafinil?

Pretty low, but I tend to find lower doses than average to be effective.

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