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If your analysis of obesity doesn't factor in hormons then it's not going to get you any working solutions.Nobody is debating that there are systematic effects. I mentioned ghrelin before, I'm obviously not ignoring the effect of hormones. But that effect is to rebalance CICO. In some ways it's behavioral, like when ghrelin impacts you satiety. In other ways, it's a thermodynamic effect like how eating protein takes more energy to metabolize than the same number of calories of simple carbohydrates. But it all still boils down to the balance of calories in to calories out.
I still maintain that's what keto is doing for you. It's giving you an easier set of heuristics to balance CICO. But at the end of the day, it's still CICO and the same principle applies to a variety of dietary choices. So keto isn't some holy grail body hack; it's just a simplified model for reducing the complexity of human metabolism to rules that ultimately reduce calories.
>Back then they said it can't work because fat has the highest energy density and will make your heart explode.
Yes, fat has the highest energy density but it's not the density that matters unless you factor in mass of fat consumed. You can still have less calories while eating fat.
If you can show that someone can have a long-term weight loss eating more calories than they burn (outside of hormone therapy) with something like a keto diet, that would be a reasonable counterpoint.
It seems to me what you're saying is "Yes, CICO is correct but hard to implement. Keto is a way to implement it." I can partially agree, but it doesn't make an understanding of CICO unhelpful. Keto can help rebalance CICO. However, it can also be used to increase caloric intake by drinking cups of olive oil. It's still keto, but it won't lead to weight loss because it's undermined the more fundamental principle. That makes the context of CICO important.
Put differently, can you lose weight by running against CICO principles and following keto? I'd say no. Can you lose weight running against keto principles and following CICO? I'd say yes. They aren't mutually exclusive, but that makes CICO a more fundamentally important principle.
It feels like we are discussing two different aspects. I'm talking about the overall strategy of rebalancing CICO. You're talking about the tactical methods to do so. The latter doesn't negate the former.