It would dependt on the concentration of fructose vs glucose in HFCS, so in theory HFCS might be diffren.
>> The 2 most important HFCS products of commerce contain 42% fructose (HFCS-42) and 55% fructose (HFCS-55). The remaining carbohydrates in HFCS are free glucose and minor amounts of bound glucose, predominantly maltose (di-glucose) and maltotriose (tri-glucose). Mention of HFCS with higher fructose content (ie, HFCS-80 or HFCS-90) is occasionally seen in the literature, but these products are highly specialized and are manufactured infrequently and in insignificant amounts.
https://academic.oup.com/ajcn/article/88/6/1716S/4617107
Eg a potato and an apple might have the same amount of carbs, but since an apple has more fructose it's more toxic (assuming we only measure toxicty based on the glucose:fructose ratio).