This depends on the DRM and the software. Software which has high international demand but is region-locked to specific countries will be pirated because of the DRM at rates that sometimes dwarf "freeloading" pirates.
I agree that Gabe is pretty much just pandering, but in the end, DRM doesn't really help piracy rates. Maybe for an immediate period after release, which is desirable in some circumstances as a matter of convenience, but that's it.
The real question is whether the piracy rate is indicative of the loss of sales due to piracy, which is clearly contested in some situations. Would Mojang profit more if Minecraft piracy was -- hypothetically speaking -- impossible? Probably a little bit, but a lot of users will look for something else to pirate, not roll their eyes and say "ugh well I guess I have to buy it now".