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I don't know what science you need to understand a system that is constantly active and is never fully allowed to rest will develop dysfunction. Anyway, as the sibling reply says, there is plenty of reputable research available to satisfy your curiosity if you wish.

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This is not necessarily a given, depending on the nature of the system, it absolutely requires evidence.

Does my circulatory system need to fully rest so as not to develop dysfunction?

Explain heartbeats?

Relatively very frequent rest and activation, I think is a charitably agreeable analogy. A heart muscle that never released would not be healthy.

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