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Put them in a locked firesafe in an accessible medicine dispenser. Put the key to the firesafe on a chain around grandma's neck.

Thank you for the idea. If I could rely on her to remember to close the door to the safe and lock it every time it would be a good option.

You can't call her and walk her through the steps or something?

Put only one dose at a time in the firesafe so if it's left open, it's empty and no one cares?

You can also buy RFID safes and RFID rings. That way you open the safe with the ring.