Anyone who has tripped balls and come out OK is not so addicted to literalness as Zuck. They realize a multiverse of perspectives lives within them. It doesn’t need to be made “real”.
In "The Doors of Perception", Aldous Huxley describes it very well: it's like these drugs remove a sensory filter we normally have in place which makes the world feel like...well...reality. When you remove that filter, you're suddenly flooded with the sense that there's so much more to the universe, but in actual fact it's all just in your head. It's just your brain cells doing a lot of communication with each other in a way that is most likely nonsensical.
Some people come out the other side thinking they've found some magic, but more likely they've just experienced what was always there without the filter, and once it wears off you're the same person you were but perhaps with a sense of feeling like you're part of a big system (which we all are, called biology).
From a strictly biological perspective it makes sense, given that most life is based on DNA and we share a lot of DNA with things that we are very different from. We share about 60% of our DNA with bananas.