Sure. To compile you only need to get the DirectX SDK (from here http://www.microsoft.com/download/en/details.aspx?displaylan...). Then open Visual Studio (I'm using 2010 Ultimate, but Express should be fine).
(these are the steps that worked for me)
Open doom.sln Go to View -> Property Manager Expand Debug | Win32 Right click "Microsoft.Cpp.Win32.user" and choose Properties Select VC++ Directories
You need to add the following directories C:\Program Files (x86)\Microsoft DirectX SDK June 2010\Include C:\Program Files (x86)\Microsoft DirectX SDK June 2010\Lib\x86
Do the same for Release | Win32.
Doom3 should now compile. Note that 2 projects might fail and 1 could be skipped.
You should find Doom3.exe under doom3.gpl\build\Win32\Release From your Doom3 installation copy the "base" folder, if you have the expansion copy that too.
Doom3 should now launch.
If you have any more problems, feel free to ask!