Putting down my bong and loading another, I remark to the travelers that the human brain is the only set of atoms in the universe which wonders why they are there. All the other atoms seem perfectly happy to exist at all.
Being a passerby on the street after hearing someone say that while they grind their next dose, I stop and comment that that was an incredible narcissistic observation for someone from a species who hasn't even colonised another solar system yet.