Highly specialized research on US levels is done at dedicated institutes like the Max-Planck-Gesellschaft, Fresenius, CERN, and many more in collaborative efforts on the EU level.
You can't have 5 research universities in a country of 5 million people.
The EU seems to be rather obsessed with achieving an end state where a huge proportion of people (like 50 per cent?) have a degree, but this necessary leads to dumbing down of the curriculum and emergence of mediocre colleges.
We already have people with bachelor degree who can barely write gramatically correct Czech, even though they are natives.
Although maybe that's what you're considering "mediocre colleges"
In the US, Wisconsin, Colorado, Minnesota, South Carolina, and Alabama are the states with populations in the 5-million range. The University of Wisconsin, Colorado, and Minnesota are all AAU members, and each would comfortably be the finest university in every country on earth smaller than, say, Spain (40 million people). South Carolina and Alabama aren't as prestigious but both do quite credible jobs of serving as the flagship universities of their states.
Really? I'm counting at least 7 research universities (ranked <200 globally) in a country of 8 million people.
https://www.google.com/search?q=switzerland+population
https://www.usnews.com/education/best-global-universities/sw...