I can make a bet that, say, OSX won't exist in its current form in twenty years. But that doesn't inform any particular action I should take today. "The end" can be a long time away, and in technology empires rise and fall in a span of three to five years.
I'd assert that the widely-accepted "in the end" kinds notions are noxious, and speak to a "happily ever after" narrative that has always been false. "In the long run we're all dead."
Another such poisonous idea is "the truth will out" -- sure, maybe. But once it does it could no longer matter, and there will likely be other far more significant falsehoods to worry about. Similarly, "Markets can remain irrational a lot longer than you and I can remain solvent." When it comes to knowledge, this might be translated as "populations can remain ignorant and make stupid decisions long enough to have irreversible disastrous consequences."