This[1] is a good summary of a talk she gave about a year ago and in it she talks a bit about the non-CICO factors in weight gain or loss. Here's one example:
“The gut microbiota of those that are lean versus those that have obesity are quite different, so much so that we can often take the gut microbiota out of individuals that are lean and place it in those that have obesity and see weight shifts with no other modifications."