Yes - totally the opposite. In fact, I think the issue with Angular is that they've not finished the work to make Angular RX-everywhere (for example, reactive components need to be manually plugged into Subjects at the moment).

With RxJS you should use it everywhere (observing state, observing component inputs, side effects etc). It's when you use it half-heartedly that you get problems with merging different programming paradigms.

The biggest issue with RxJS that we've found is that some devs have a super hard time getting to grips with the paradigm, and if your project is mostly those types of people, it will end up a disaster.