I have tried the QubesOS and boy does it bring back memories of Windows being called Pentium to 286 converter. It is slow as molasses on hardware where even Windows 10 and Gnome are both fast and to make it usable you have to keep relaxing the security to the point where it is probably less secure than regular OS. And don't even bother if you have to use scaling other than 100%, sure you can scale the DOM0 but the rest of the VMs are not scaled and there is no documentation on how to do it. What we need are simple sandboxes that isolate GUI applications into chroot environment and keep them away from other applications and documents.