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Comment by ck2 | Hacker News Reader

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ck2·

Paper is fascinating to the right interests but oddly extremely specific for HN?

Do some people just not have Slc25a51? Does this matter?

Is this supposed to be some kind of longevity insight?

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I think this is relevant to the biohacker crowd and much of the NAD+ (and NMN) interested crowd (such as followers of David Sinclair or David Attia), and topics around the Yamanaka factors & Hormesis induced from existential threats (such as heat/cold or fasting, or fasting mimicking things like metformin inducing low blood glucose in otherwise healthy people)

I'm not a doctor or a researcher etc. Just a guy who likes to watch these things play out and barely understands what I hear :)

> David Attia

Did you mean Peter Attia?

Yes, my brain got stuck on "David" xD

NAD+/NADH is kind of an important energy transporter molecule in your body. If you do not have NAD+ to be reduced to NADH, your body cannot oxidize NADH to power the electron transport chain and drive forward ATP synthase.

In other words, you will die literally from exhaustion.

And humans and the other animals make these substances from the various forms of vitamin B3, e.g. niacin or nicotinamide, which must be provided by the food.

Insufficient intake of this vitamin causes the disease named pellagra (which was frequent at people who ate almost only corn, i.e. maize, with too little of other vegetable or animal food).

I am also a long time hacker news reader and even a longevity and biology enthusiast, and I can confirm that I also have no idea what any of this means or why it is on the front page

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