If you live in Canada, and specifically in Vancouver, there are de facto legal operating dispensaries for psilocybin [0]. If you don't live there, but live in the USA, some of said shops will ship products to USA. Now, I don't know if this hits your threshold for "safe", but seeing as the doses involved are quite low, one could argue that it would be safer than, say, starting a new (SSRI) antidepressant if you take into account long-term effects [1], side-effects, etc [2].

[0]: https://www.cbc.ca/news/canada/british-columbia/magic-mushro... [1]: https://news.ycombinator.com/item?id=29024808 [2]: https://www.nature.com/articles/s41380-022-01661-0