I’m interested to know more about how NMN/Metformin/Resveritrol didn’t pan out in humans as all the mice studies seemed quite promising.
If you want that "one weird trick that doctors hate", OMAD alone is almost magical. I've been suggesting it to everyone I know just so they can do something easy and simple to get a few free years out of their fleshy meat body. Also, because of OMAD, I now spend less time prepping food, eating food, and other food-related tasks. Even if OMAD had no health effects (positive or negative), I'd keep doing it as it has freed up a surprisingly large amount of time.
It's also a lot easier to track macros and "eat like it's your job".
And I do indeed seem to be enjoying better overall health than a lot of people my age or even 10 years younger. They're all starting to complain about their knees and backs and they're on various medications and I have none of that yet.
Of course you can't read much into that by itself, and I'm not going to write my entire life's details here, but still it doesn't conflict with the theory either.
I'm also very thin. Thinner than most people probably want to be, especially males, at least Americans.
Athletes have been employing OMAD to increase their athletic performance, and have reliably been doing so, so I guess the answer to your other questions is yes, OMAD plays well with those goals.