Comment by DiabloD3 | Hacker News Reader

Comment by DiabloD3 | Hacker News Reader

The NMN research didn't pan out in the end, just throwing that out here.

There is something involved in NMN, but taking it (or any of the precursors or metabolites) alone doesn't actually seem to reliably cause what they were looking for.

Most likely, it's something like the curcumin vs ground turmeric issue (curcumin doesn't work alone, it combines with another chemical found in turmeric to produce the active chemical, and none of the curcumin supplements work), or with glucoraphanin and myrosinase to produce sulforaphane (popularized by Dr Rhonda Patrick; sulforaphane is short lived, and you need to package them correctly to not self-react in a supplement while it's sitting there on a shelf, so the delivery mechanism is the hard part), or with the flavor of garlic, allicin, another short lived chemical produced by alliin and alliinase (which is why crushing garlic is important instead of slicing, and ground garlic and factory produced minced garlic will never have that magical flavor).

Also, as for Omega 3, watch https://www.youtube.com/watch?v=-f-CFQxaUY4 Dr Rhonda Patrick interviews Dr Bill Harris; the main take away from this isn't that it works (we all know that already), it's what the dose range is: we're all underdosing.

Have you got a reference for "NMN didn't pan out in the end?" I thought it Worked really well in mice and early human trials didn't find nasty side effects. It's too early to tell if it increases lifespan in humans as those experiments take a long time. https://link.springer.com/article/10.1007/s11357-020-00165-5 https://www.sciencedirect.com/science/article/pii/S155041311...

I’m interested to know more about how NMN/Metformin/Resveritrol didn’t pan out in humans as all the mice studies seemed quite promising.

Metformin did pan out, but the research seems to indicate One Meal A Day would have to be employed with it, as Metformin seems to interfere with autophagy. Lack of autophagy seems to be the biggest cause of the effects of old age, as the Western Diet pounds 3 meals a day, which means our insulin levels never drop to the autophagy activation level.

If you want that "one weird trick that doctors hate", OMAD alone is almost magical. I've been suggesting it to everyone I know just so they can do something easy and simple to get a few free years out of their fleshy meat body. Also, because of OMAD, I now spend less time prepping food, eating food, and other food-related tasks. Even if OMAD had no health effects (positive or negative), I'd keep doing it as it has freed up a surprisingly large amount of time.

No chance to convince my parents to do OMAD. But would like to try it myself. How big are your meals if I may ask? Actually would like to start going to gym again and gain weight/muscle mass, so would be really interesting to hear if that could work with OMAD.

They're approximately 3 times bigger. I eat my ~2000 calories in one go.

It's also a lot easier to track macros and "eat like it's your job".

This is interesting. I've been eating only once per day ever since I started feeding myself, but not because of a conscious plan. I just can't handle any more, unless I also engage in very physical activity. To answer the other comment, the size of that one meal is the same as anyone else's ordinary dinner, not larger.

And I do indeed seem to be enjoying better overall health than a lot of people my age or even 10 years younger. They're all starting to complain about their knees and backs and they're on various medications and I have none of that yet.

Of course you can't read much into that by itself, and I'm not going to write my entire life's details here, but still it doesn't conflict with the theory either.

I'm also very thin. Thinner than most people probably want to be, especially males, at least Americans.

Autophagy is the process by which the cells clean up and recycle. It is promoted by intermittent fasting. Stay healthy my friend!

Is OMAD also a good idea if you struggle to maintain/gain weight even with 3 meals a day? Is it consistent with making progress in sports, i.e. getting stronger/faster/increasing endurance? Is it consistent with outdoor activities like walking/hiking ~25km/day?

OMAD might help with it. OMAD just dictates when you eat your food (once a day instead of splitting up into three times a day) but may make it easier for you to track your calories/macros.

Athletes have been employing OMAD to increase their athletic performance, and have reliably been doing so, so I guess the answer to your other questions is yes, OMAD plays well with those goals.

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