Then you know all that is to be known about what an human is.
You don't need to understand "dolphin-ness" to know that by enabling a dolphin to talk or fly you created a post-dolphin.
Post/Transhumanism is not just about physical changes. Those changes , of course, will create/lead to philosophical/metaphysical questions, but no one understands transhumanism as a "branch of philosophy that questions itself about ...."