We are likely to build support for NaCl in the future.
On the server-side, there is no requirement for a client to install a plug-in - it's for high-performance on the server i.e. semantic analysis, compute bound problems etc
Last point - we also think a lot about hybrid models where performance can be accessed on both client and server. This is much longer term, but the design of Fabric allows for it.
You can how we've extended Fabric to include existing C++ libraries - great for custom data types, streaming data etc
It is not really a consumer web technology - we're acutely aware of the plug-in friction/antipathy. However - if you want HPC in the browser, this is one of the only ways to do it.
But yes, they do have a plugin version of Fabric. I have similar misgivings about that.