[next @~1mya (the lower orange (North America) caballine arm from node 3): leading to E. caballus (green: Eurasia) --> domesticated [1] horses]
Regarding the causes of the Late Quaternary extinctions [2] it is pretty hard to pinpoint a single cause e.g. climate change etc. and there are a lot of hypotheses floating around (probably the most curious/spectacular of the bunch: younger dryas impact theory).
But at some point regardless of the causes - approx. 10.000 years ago - there are no traces found of (wild) horses in the Americas, anymore; they only reemerge again with the reintroduction by the European colonists in the 15/16th century.
[0]https://elifesciences.org/articles/29944/figures#content
[1]https://www.nationalgeographic.com/science/article/horse-dom...
[2]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8654998/#!po=32...