That said there's no doubt there's in my mind economic conditions contribute. The paths to middle class prosperity in the US are fewer and further between than they used to be. That deprives many of even the aspiration of a better life, leading to nihilism, which can be witnessed in many contexts outside mass shootings (what media is popular, sentiment polls, etc).
I also wonder if our Architecture itself contributes. A lot of bedroom community suburbs seem designed to create social isolation. They're just collections of crash pads for long commutes with no communal gathering places.