The biggest difference to my mind, the one that bugs me most, is the opportunity cost. Sure, I have no commute, low mortgage for a big house, no sales tax and easy access to some of the most beautiful unspoiled wilderness in the entire world. The downside is that there are virtually no jobs/startups here that I find interesting.
You either adjust your expectations when you live here, or you go somewhere else.
I am somewhat worried that when I do decide to leave that my wages will be pegged artificially low because of the cost of living difference. But I figure I can always convert my salary to the local equivalent when asked what my current salary is.