You'll like what we've done during my Hackathon https://github.com/fork-tongue/collagraph/pull/66

We added support for PyScript using Collagraph, which allows you to define single file components with a Vue-like syntax.

Excerpt from the project README:

Write your Python interfaces in a declarative manner with plain render functions, component classes or even single-file components using Vue-like syntax, but with Python!

- Reactivity (made possible by leveraging observ)

- Function components

- Class components with local state and life-cycle methods/hooks

-Single-file components with Vue-like syntax (.cgx files)

- Custom renderers (PySide, pygfx and now PyScript)