If I'm going to be bound by the limitations of how immature WebAssembly is right now, I'd at least use its more mature ecosystem for development, which is Rust. And actually, I recently began doing so in my free time with a framework named Yew[1].
I know that it's unrealistic to expect Python to be a first-class citizen in browsers as JS is, but at some point we'll grow tired of reading "X language is now available for browsers" when it's more like "X can do WASM now".
edit: Anyway, I don't want to come off as under-appreciative of PyScript. I'm sure a lot of people will love it and make it grow a lot. I'd probably give it a try someday too. Props to the developers!