Thinking about it more, there is probably a more general U curve for exercise. For example, I used to see an ex-NFL running back in the gym sauna. He could barely move most days before 30+ minutes in the heat.
I power lifted for almost 15 years before scaling back because of age. I feel like I ended up hitting a sweet spot, but was always careful. Even before I really cut back I had quit doing singles for awhile.