Yeah, I've done some useful things with pygame. My game business almost entirely uses Unity, but I do find that Python is helpful for tool development as, like you, I know the language well. Often it's a lot speedier to write a quick visual tool in Python that generates a bunch of json data that gets loaded in as a text asset and parsed, than it is to write the same thing as an editor plugin (at least for me!) Using Python + pygame or Python + PySDL2[0] gets you rendering stuff on the screen and receiving input, fast.

I've also used the Twisted Matrix[1] for some online TCP-based game server work, and that was pretty positive, though the library is quite daunting to figure out. That was 8 years ago though, perhaps there are better libraries nowadays.

Writing an entire game in Python might be an uphill struggle though. The interpreter is really slow, so a JIT alternative like Pypy[2] is very necessary. On my game server project I remember having to use a combination of Pypy and writing the tightest inner-most parts of my simulation loop in Cython to get the server tick to the target. As much as I love Python, if you're comfortable with Godot, it's probably a better long term investment with fewer headaches along the way.

[0] - https://pypi.org/project/PySDL2/

[1] - https://twistedmatrix.com/trac/

[2] - https://www.pypy.org/