This is standard at least across Chrome and Firefox on Linux and MacOS— (ctrl|cmd)+R does a normal page refresh, (ctrl|cmd)+shift+R does a "hard refresh" where it reloads every resource on the page without caching.

Also, in Chrome, if and only if you have the dev tools open, right clicking the reload button will give you a menu with the options "Normal Reload", "Hard Reload", and "Empty Cache and Hard Reload". The third option will ensure that requests initiated by JS or that otherwise weren't part of the page load also won't be served from cache.