1. The increased iOS-ification of the user interface. I believe a desktop operating system should support desktop workflows and not import at wholesale UI elements that don't make sense outside of touchscreen environments; I have a similar complaint about modern Windows and GNOME.
2. The introduction of notarization.
3. Over the years I've noticed that macOS has gotten more annoying when it comes to notifications. Back in the Leopard era there was a classic commercial mocking Windows Vista's "Cancel or Allow" dialogs. Yet it seems I have to wade through many notifications whenever I'm using Macs these days.
In my opinion, it seems that the old guard from the days of the classic Mac, NeXTSTEP, and early Mac OS X with their deep knowledge of the UI guidelines of those eras has less and less influence at Apple these days, while younger software developers with little-to-no experience with these operating systems but who have extensive experience with the Web and newer operating systems are having more influence on the Mac's UI/UX. Unfortunately the Mac is becoming more like iOS and less like an operating system completely tailored to the desktop computing experience. Don't get me wrong, modern macOS is still a good OS, but I prefer the Snow Leopard era of Mac OS X.