I've worked on a game which aimed for authentically retro pixel art, but in hindsight I think it was a silly misallocation of resources. There's a reason it's so uncommon nowadays. If I were to try again, I'd at least include high-resolution 2D transforms in the engine, and possibly dynamic lighting too.
I briefly explored the possibility of developing a style-preserving realtime rotation algorithm for sprites, but it's a hard problem.