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Comment by jamesblonde | Hacker News Reader

Epigenetics is fascinating. I just came back from a project meeting, where i work with people who discovered that HRT (hormone replacement therapy) slows down epithelial cell aging. Epithelial cells are the cells that cover all your vital organs, so they are important for aging.

Now, there are even commercial companies that measure Epigenetic age of cells with a technique called DNA methylation.

References: https://investinaustria.at/en/news/2022/03/epigenetic-clock-...

https://www.mydnage.com/?gclid=Cj0KCQjwheyUBhD-ARIsAHJNM-Mrk...

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DNA methylation is not a technique that can be applied. It is a biological system present in your cells silencing expression of genes that are not useful for a cells current behavior. Differently differentiated cells have different "genes methylated" and thus inactivated which govern their behavior and potential for further sub-differentiation. Indiscriminately "reversing methylation" would probably lead to a lot of "cancering".

You don't apply DNA methylation - it is the basis for measuring epigenetic age. I mentioned HRT as one way of reducing epigenetic age for epithelial cells.

Right, just wanted to clear up the concept.

The reference you gave measure blood or urine samples which would probably not be representative of epithelial cells. Also i like non-descriptive but professional looking stock photos of multi-pipettes and the ubiquitus vortex genie 2. Extra points for consecutive photos of the same tip-rack in obviously proffessional use.

Time to hit up my gymrat brother for some testosterone I guess!

Not sure riding high on dirty test (dosing TRT levels off toilet test going around gyms will be next to impossible) will slow down ageing - but it will probably make you juicy. Make sure to hit the gym to double the gainz.

Oh, forgot to add that my brother is also an MD resident ;) Although he’s doing opthamology :/

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