"If it always worked, it would be business. Let's go to the pub." -- Me, consoling a grad student after experiment failure #24.
More seriously, if you're in basic science, your skills are valuable in transforming the work into a more useful thing to be used later. Using your science factory model, you have created a reusable widget that other people can use. The science factory model does work, you can see its results in things like MIAME: https://www.nature.com/articles/ng1201-365 Where large pooled datasets are used to get insights otherwise impossible.
There's not a ton of low hanging fruit in some fields, as time has gone on the edges are harder and more expensive to see to be at the cutting edge. Ex: you spend $2M on a microscope that does a cool thing and two years later the new model is all that, a bag of chips, and a soda for the low price of $750k. You hope you have a good enough relationship with the vendor that they will either mod or upgrade your system, or that those two years were enough for you to get ahead. It probably wasn't. And you now have a not as fast ferrari for more money than the fast ferrari.
There is a massive glut of international students willing to work for basically nothing, beholden to your PI by their visas. I say this not as xenophobia, but I was the only working class American (my parents do not have degrees) in the department. All students/postdocs that I worked with were from other countries, or if they were American, their families were doctors, or a faculty member. More generally, the kind of people that might own horses :D.
No firm would take this work on, as the profits are not clear, and the time scales for success range from two years to never. In this case success is "great job publishing, we'll give your lab another 2-3y of funding." After which, you better get good at writing books and eating pasta.