I've literally sat in meetings trying to get access to scientific projects I'm interested in and applied for jobs even at the university I already worked at in similar capacities, and yet, it's filled with PIs just wanting grunt labor (i.e., what they're used to from graduate students) to build things that they understand or you absolutely never hear back or the pay is a third of what you already make. And then there's pockets of software people in this niche world that only want to do things their way, because that's all they've ever done, and they can really be quite obstinate. They're like this massive pillar you must somehow work around.
I really, really, really like writing software in scientific contexts, but it's such a quagmire. I'd like to return to that world some day with the lessons I've learned outside of it. Software in support of an interesting domain or context is just really fun. I've also tried getting a job at an architecture firm that had some very neat ideas for building out a tool, but the response was basically the same as described above.