This sounds like a great set of constraints for an industrial controller, or a custom Cyberdeck-type portable.
I’m confident any device following these guidelines would be DOA in the larger market, though. Even _if_ you could source things like LCD assemblies that fit your criteria, the expected density (high) and labor costs (low) people have for modern electronics don’t leave a lot of room for this kind of bespoke design.
I’m extremely impressed with how far Framework got on the path to “full repairability” using off-the-shelf parts without producing something that looks like a late-90s Thinkpad.
Don’t get me wrong: I love the old IBM, Tadpole, Toshiba, et. al. designs, but I don’t think that many people outside this community would be willing to pay 2-3x as much for something 2-3x larger and heavier and several generation behind in terms of performance. (Not to mention wildly incompatible with any non-hobbyist OS.)
OTOH, what you’re describing does sound a lot like why custom, hand-wired audio amplifier builders do. They manage to make a business out of it, mainly by appealing to folks willing to spend effectively unlimited money to get that “special something”.