This is in contrast to biking or rowing at a moderate pace (pusing myself and getting pretty sweaty but not collapsing or wanting to barf) for an hour once or twice a week. If I do this, I am still less fidgety but I feel more mentally fatigued later on the day, and sometimes the morning after, I exercise. I attribute this to nutrition/glucose levels and hydration, but even drinking a ton of water and snacking won't fully ameliorate the issues. The same thing happens after a weekend of playing hard, like kayaking one day and hiking with my daughter in my backpack the next day. I'm often pretty unproductive on Monday (oh well... ;)
What works best for me is moderate weight lifting followed by like 30 min of moderate rowing or biking, twice during the work week. Although I might feel a bit more depleted after rowing than not, my overall energy level is higher than if I skip the cardio, and I recover more quickly from my weekend activities.