Just tried on my Framework with Ubuntu 22.04:

$ sudo powertop --auto-tune modprobe cpufreq_stats failedCannot load from file /var/cache/powertop/saved_results.powertop Cannot load from file /var/cache/powertop/saved_parameters.powertop File will be loaded after taking minimum number of measurement(s) with battery only RAPL device for cpu 0 RAPL Using PowerCap Sysfs : Domain Mask d RAPL device for cpu 0 RAPL Using PowerCap Sysfs : Domain Mask d Devfreq not enabled glob returned GLOB_ABORTED Cannot load from file /var/cache/powertop/saved_parameters.powertop File will be loaded after taking minimum number of measurement(s) with battery only Leaving PowerTOP

powertop --auto-tune is kind of annoying to use, it usually winds up tuning something that shouldn't be and there's no convenient way to filter what it does, and then suddenly your mouse stops being responsive if you leave it alone for more than 2 seconds.

Also on a laptop you might have stuff being plugged and unplugged all the time. Tbh it's kind of surprising systemd hasn't grown a "powertop that remembers things" arm.