I use tiddlywiki (with the nodejs setup) regularly. It's great until your wiki grows too large, at which point you need to wait ~10s for it to load even with modern hardware.
Not to mention downloading and parsing 20mb-worth of html+js each time you open up the wiki can be quite slow.
As for lazy loading --- when enabled, it breaks the indexing (e.g. finding backlinks) and searching because these are done by the js inside the browser too. I only lazy-load images and binaries because they are not indexable anyway.