"The solution to pollution is dilution"
I mean that can't possibly be a full solution but could a major "win" on life span or at least health span be as simple as some kind of dialysis session?
Could this also be a hidden mechanism involved in some of that hyperbaric oxygen chamber evidence for life/health extension? Maybe all that oxygen oxidizes and destroys some of this stuff.
It's obviously the right choice in the elderly/ill, but for a healthy young person maybe it's better to exercise/strengthen the body's natural abilities in these departments. I think one of the arguments for intermittent fasting is to clean up the detritus being kept around for energy sake, via natural mechanisms...
The best example of stuff literally accumulating macroscopically in your body (besides the impressive images of Lipofuscin) is metals accumulation in bones. They cause a lot of damage, including a major cause of neurodegeneration. They can be removed via chelators.
BTW I would avoid hyperbaric at all cost even if hornesis is a thing. Oxygen is literally the reason we are all slowly dying, we oxidize and implode. But don't refrain from breathing, hypoxia incurs more damage. If you want to prevent oxidation you need Skq1.
It was probably in this paper https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422527/
Google Skq1 on pubmed to see how great it is
I haven't been able to find a paper describing a mechanism, but my literature review tends to specialize in hymenopterological ethology, so I don't know that I would find such a paper even if it exists. The correlation is uncontroversial, though, and I suppose it might not be a surprise to see it demonstrated that the cause is in fact the accumulation of errors in the genome that's half-duplicated during spermatogenesis.
Individuals do get less good at it over time, though. The structures described earlier as "shortening" are called telomeres [1], and they do actually do that, as a result of DNA copying being a physically somewhat destructive process. They're purely structural rather than informatic, though, and everyone starts out with a fresh set.
I had an internship at the New York State Psychiatric Institute (before I moved into software development). Paternal age was used as one factor in determining if people were at risk for psychotic breaks (schizophrenic prodromes) by one of the assessment tools they developed.
[1] https://www.lifespan.io/news/recombinant-serum-albumin-incre...
A personal experience that comes to mind is when my childhood cat developed kidney disease.
She drank plenty of water, urinated excessively, and her blood still became toxic without regular (~daily) intervention in the form of adding saline to her blood intravenously. Like a light switch she'd resume normal life after the saline bag emptied into her blood, then slowly become ill again in the next 24-48hrs.
J/K
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I had a cat when I was in my 20s that got into a fight some eve...
Its face got infected and blew up. It was $8,000 for surgery, and I couldnt afford it - so had to put her down... but I did love that cat, and I would have paid it if I had it...
Excessively drinking water, excessive urination, and renal failure are all co-morbidities for cats. Either way, kudos for helping them.
>Excessively drinking water, excessive urination, and renal failure are all co-morbidities for cats. Either way, kudos for helping them.
Those particular symptoms are common (in cats at least) to feline hyperthyroidism, which is significantly more common than feline diabetes.
Not saying it wasn't Diabetes, but Hyperthyroidism seems more likely.
But gently cutting your arm open and draining a pint into the sink will do the trick!