Transfusion of brain fluid from young mice improves memory in old mice
statnews.com
statnews.com
"The solution to pollution is dilution"
I mean that can't possibly be a full solution but could a major "win" on life span or at least health span be as simple as some kind of dialysis session?
Could this also be a hidden mechanism involved in some of that hyperbaric oxygen chamber evidence for life/health extension? Maybe all that oxygen oxidizes and destroys some of this stuff.
It's obviously the right choice in the elderly/ill, but for a healthy young person maybe it's better to exercise/strengthen the body's natural abilities in these departments. I think one of the arguments for intermittent fasting is to clean up the detritus being kept around for energy sake, via natural mechanisms...
The best example of stuff literally accumulating macroscopically in your body (besides the impressive images of Lipofuscin) is metals accumulation in bones. They cause a lot of damage, including a major cause of neurodegeneration. They can be removed via chelators.
BTW I would avoid hyperbaric at all cost even if hornesis is a thing. Oxygen is literally the reason we are all slowly dying, we oxidize and implode. But don't refrain from breathing, hypoxia incurs more damage. If you want to prevent oxidation you need Skq1.
It was probably in this paper https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422527/
Google Skq1 on pubmed to see how great it is
A personal experience that comes to mind is when my childhood cat developed kidney disease.
She drank plenty of water, urinated excessively, and her blood still became toxic without regular (~daily) intervention in the form of adding saline to her blood intravenously. Like a light switch she'd resume normal life after the saline bag emptied into her blood, then slowly become ill again in the next 24-48hrs.
J/K
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I had a cat when I was in my 20s that got into a fight some eve...
Its face got infected and blew up. It was $8,000 for surgery, and I couldnt afford it - so had to put her down... but I did love that cat, and I would have paid it if I had it...
Excessively drinking water, excessive urination, and renal failure are all co-morbidities for cats. Either way, kudos for helping them.
>Excessively drinking water, excessive urination, and renal failure are all co-morbidities for cats. Either way, kudos for helping them.
Those particular symptoms are common (in cats at least) to feline hyperthyroidism, which is significantly more common than feline diabetes.
Not saying it wasn't Diabetes, but Hyperthyroidism seems more likely.
But gently cutting your arm open and draining a pint into the sink will do the trick!
I haven't been able to find a paper describing a mechanism, but my literature review tends to specialize in hymenopterological ethology, so I don't know that I would find such a paper even if it exists. The correlation is uncontroversial, though, and I suppose it might not be a surprise to see it demonstrated that the cause is in fact the accumulation of errors in the genome that's half-duplicated during spermatogenesis.
Individuals do get less good at it over time, though. The structures described earlier as "shortening" are called telomeres [1], and they do actually do that, as a result of DNA copying being a physically somewhat destructive process. They're purely structural rather than informatic, though, and everyone starts out with a fresh set.
I had an internship at the New York State Psychiatric Institute (before I moved into software development). Paternal age was used as one factor in determining if people were at risk for psychotic breaks (schizophrenic prodromes) by one of the assessment tools they developed.
[1] https://www.lifespan.io/news/recombinant-serum-albumin-incre...
I read it this morning and the concept of changing CSF in order to have an increase in oligodendrocyte progenitor cell proliferation and differentiation is such a creative idea; a lot of the idea has focused on increasing flow in order to move waste, etc with csf. I think this concept that CSF is also acting as an important mechanism to moving factors that will cause up regulation, etc, is very novel.
honestly one of my favourite papers in the last five years, I am obsessed.
A few medical device startups have attacked the problem with promising results. Unfortunately, VC and national funding orgs aren't particularly interested in device based solutions because pills and injections are perpetually 5 years out.
I'm aware of at least one that was able to halt or reverse alzheimers in a 200 patient trial, but folded after they couldnt get funding to move forward.
There was also benefit across most measures, but just not of statistical significance.
The trial had some major problems with appropriate controls, and is widely cited as a poster child for why the FDA should not require a control group to undergo invasive brain-surgery, and how this can taint the results.
It also showed a 89% reduction in amyloid Beta, the same proxy measure Biogen's aducanumab was recently approved based on.
There are a lot of treatments that's worth dumping several million dollars in even if they are low probability of having durable effects.
I obviously have biases and an axe to grind, but these are my opinions.
however, the ideas of 1) replacing csf from young to older mice and 2) the idea that there are factors in CSF that are being delivered to other areas of the brain and promoting cell proliferation: that's pretty novel.
all of the literature right now points to csf in terms of waste clearance and csf is painted as almost a river that picks up components and moves waste (e.g. amyloid beta) from the periarterial areas in the parenchyma and then out through the perivenous areas into the lymphatic system. and this means that the idea of delivery of promoting factors is really interesting.
This is why the SV billionaires need to create the metaverse. The matrix had a the right idea, just keep the young plugged in to VR and use machines to do the dirty work.
This old-eating-the-young thing has been going on for time immemorial. It's encoded into our mythology, of Saturn eating his children so that they wouldn't usurp him. And it's not just our (i.e. Western) culture either.
No, It’s because Peter Thiel was (perhaps still is) reportedly interested in it, and that was a big enough story to be eventually lampooned by the comedy show Silicon Valley.
I would like an account of various bodily components, grown from my personal stem-cells, for injection / growth / use as I see fit.
My Stem Cells My Choice.
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(for example, I want to regrow my eyeballs.)
Note that your eyeball metabolism can be significantly rejuvenated, e.g retinalamin often reverse blindness in humans. Or Skq1/visomiten. Glaucoma and macular degeneration are totally solved problems. As for myself I want to shrink my eyeballs (myopia) but this is not pharmacologically doable (because extremely undefunded) although Berberine do very significantly slow the myopia progress.
If you're interested in aging topics, he did a recent debate with Dr. Aubrey de Grey: https://www.youtube.com/watch?v=MJIvp_J-kzM
In all seriousness, I wonder if this can be synthesized. A transport layer for brain conductivity, just replace the fluid. Maybe create an even better fluid than what the young hosts have.
Jiffy Brain franchises on the way.
you can classify memory into many different components, and how memory in mice translates into humans is not extremely clear.
we can do experiments that do fear conditioning, or classic conditioning and operant conditioning, but the translation from mice to humans is definitely not clear cut. I think this is one of the biggest weaknesses of the paper actually
I was imagining Elon and Jeff keeping a stable with the equivalent of vampire "blood bags".
From the juices of the dying"
Shriekback, Nemesis, 1985.
As conspiracy theory, it predates Trump/Qanon, we’ve had David Icke with his adrenochrome from children sucking reptilian royalties
Surely this will give more fuel to the conspiratorial fire.
My kid: Sure, pops, why?
Me：Well, I have a little favor to ask…
The day old-gizzards figure out how to sip on young-people juice and live forever, we are truly screwed.
An old tyrannical movie villain dies and a to-be old tyrannical movie villain is born. Billions of people shouldn't be sentenced to death just because the world might be a bit better off if a few people weren't immortal.
You can be almost sure that once the underlying mechanism is known, the necessary stuff will be synthetised instead of being transferred from a young person to an older one. If only to guarantee stable supply, consistent quality and rule out accidental transmission of various pathogens from the donor.
Tyrants aren't even forever even if they never die of old age. After all, tyrants can meet their end through constantly replacing their followers with yes-men to the point of becoming increasingly detached from reality. This may prevent them from noticing certain features of reality such as military incompetence of their force.
The suicide of Hitler certainly was a horrible tragedy to his close family and those who believed into him — for many others it was a reason to celebrate. Similarily death of a young family member can be traumatic to the max, while the death of grandmother which everybody (including herself) already accepted and comes after a live well lived can be even have a certain beauty to it.
Death is not that simple.
Most of the longevity research is trying to stretch healthspan. Stretching lifespan as such is a nice side effect.
We aren't likely to live forever anyway.
I don't like the idea of dying, but the slow slide into immobile sinility is positively terrifying.
I'm in my 40s. I've resolved to look after my health not to live longer, but to extend my health for as long as possible. I'm determined to stay active, mobile and socially/intelectually engaged for as long as I can, partly for my self, but also for my kids.