Every one has challenges. Claiming certain groups have more challenges implies being able to measure the difficulty of challenges, in order to be able to ascertain the challenges of one group are greater than the norm.
I can tell you with near certainty that the apartment building has more concrete. Even if I've never been inside it.
Likewise, I can't measure the amount of challenge I faced (they were significant), I can't tell you the amount of challenge a trans kid faces. I can tell you with near certainty the trans kid faces more.
You don't need to measure, you don't need to be exact. Opportunity is wildly uneven right now. We can absolutely level things, and worry about whether we over corrected later.