The scaling artifacts are no different at 4k compared to running an MBP at "non-native" retina resolutions - its the same problem/issue, if you are sensitive.
For what its worth, Apple have shipped many MacBook Pros at "non-native" resolutions by default for years, so... The 15 inch for years was a 2880 x 1800 panel, which is only Retina native at an equivalent of 1440x900. Apple shipped them in the non-2x 1680x1050 mode by default.
The same is also true of the current 13inch M1 MacBooks 2560 x 1600 (1280x800 at 2x), but apple run them out of the box at non-2x 1440x900.
All of this is to say not even Apple themselves stick to "2x retina" only resolutions on their own laptop hardware - running a 4k monitor at non-2x retina scales isn't that much different, and most people will be perfectly happy with scaled resolutions on a 4k 27 inch panel or similar in my experience on macOS.