Whenever people bring up Lisp syntax, I like to remind everyone about io language. Its homoiconicity is inspired by Lisp, and almost all good things about Lisp syntax are applied in io, but at the same time it avoids this awkwardness that turns away most of the people (and turns the remaining minority into zealots :-)
So if you design a language and want to use Lisp-like syntax, I recommend to also check out io before steaming ahead.