CFOP is definitely more finger friendly (no middle layer changes), but I think Roux has fewer regrips, at least at non-speedcube levels (maybe I'm wrong, but I never change the orientation). Roux is also considered more "intuitive", there are points where you can look at the cube and (after a while) just see what needs to be done.
I don't do it for speed, so I haven't bothered learning all the algorithms. I'm "fast enough", but I probably only do 10ish solves a day, and Roux makes it really easy to remember the 3-4 algorithms needed to solve that. It still amazes people when you can do it, and even taking 90 seconds to do it, but with hardly any pauses, still makes people think you're a wizard or something.