Not for me. Bootstrap is very mature, has sane UX, is adaptable, has a good balance between general styles and utility classes. I find that Tailwind clutters your HTML and I fail to see the benefit over writing pure CSS in isolated components in a framework like e.g. Svelte. The reason I would use a CSS framework in the first place is to avoid having to write everything from scratch myself. All (the free parts of) Tailwind affords is an indirect way of writing styles using classes. In that case you might as well bite the bullet and learn CSS properly.