Yes, I’d say that interface makes enough of a difference such that musicians enjoy the challenges they present. And from my experience, this influences the outcome of the work, which presents interesting possibilities.

For example, consider the following scenarios:

1. Musician is sitting at a desk, drawing midi notes on a screen, much the way he might enter data on a spreadsheet.

2. Musician is standing over two independent hardware synth/sequencers, twiddling knobs, usually in sync with the tempo. That standing position might even incline him to dance. The body is now playing a significant role.